AmpathChat_67 Update on Paternity Testing

The term paternity testing, parental testing and human identity testing are interchangeable. Paternity testing refers to the use of genetic fingerprinting to determine a biological parent-child relationship.

AmpathChat #66 - The aetiology, diagnosis and management of the vaginal discharge syndrome

The vaginal discharge syndrome may be secondary to vulvovaginitis or cervicitis. Both of these conditions have infectious and non-infectious aetiologies.

AmpathChat #65 - Molecular Pathology of Lung Cancer

Worldwide, primary lung cancer remains the most common malignancy after non-melanocytic skin cancer. The World Health Organization (WHO) estimates lung cancer to be responsible for 1.59 million deaths globally per year, with smoking playing a major contributory role in 70% of cases.

AmpathChat #64 - The Diagnosis of Vitamin B12 Deficiency Revisited

Vitamin B12 deficiency can lead to devastating disabilities, morbidity and even death if not diagnosed timeously. Prompt diagnosis and treatment of Vitamin B12 deficiency can easily reverse the wide range of debilitating neurological and hematological symptoms associated with Vitamin B12 deficiency.

AmpathChat #63 - Pharmacogenomics

It is well established that unique patient characteristics exist to guide therapeutic drug decision making. These assist in optimising drug response and minimising adverse drug reactions (ADRs), and include age, weight, diet, co-morbidities, liver and renal function, as well as drug-drug interactions.

AmpathChat #62 - Pneumococcal Serotype-Specific Antibody Testing

Patients suffering from recurrent infections, autoimmunity or lymphoproliferative disease may have an underlying humoral immunodeficiency.

AmpathChat #61 SA Dyslipidaemia Guidelines

In 2016 the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) revised guidelines for the management of Dyslipidaemia.

AmpathChat #60 Stem Cell Transplantation

Haematopoietic stem cell transplantation (HSCT) is any procedure where haematopoietic stem cells of any donor and any source are given to a recipient with the intention of repopulating the haematopoietic system in total or in part.

AmpathChat #59 Diagnosing Pulmonary TB

According to the World Health Organisation (WHO) Global Tuberculosis Report of 2018, an estimated 10 million new cases of tuberculosis (TB) were reported in 2017.

AmpathChat #58 Influenza

Influenza is an infectious respiratory disease caused by the influenza virus. It can range from a mild infection to a severe life-threatening disease.

AmpathChat #57 Hypercalcaemia a Diagnostic Approach

Hypercalcaemia is a relatively common clinical problem. Primary hyperparathyroidism and malignancy are the most common causes of hypercalcaemia

AmpathChat #56 Cystic Fibrosis

Cystic fibrosis (CF) is one of the most common life-limiting autosomal recessive conditions in South Africa. CF is increasingly being recognised in all of South Africa.

AmpathChat #55 - Tissue typing: HLA typing and screening

Ampath Immunology is proud to announce the introduction of HLA tissue typing and antibody screening using Luminex PCR-based multiplex technology.

AmpathChat #54 - Helicobacter pylori: an update

Helicobacter pylori is a highly prevalent curved gram-negative bacterium. Seropositivity rates in South-Africa range between 60% and 100%. It causes more than 90% of duodenal ulcers and up to 80% of gastric ulcers. Atrophic gastritis due to H. pylori can lead to gastric cancer.

AmpathChat #53 - Molecular testing in colorectal carcinoma

Colorectal carcinomas arise from colorectal epithelium, which has undergone a series of molecular changes, referred to as the adenoma-carcinoma progression sequence.4 With increasing genetic mutations, progression from normal epithelium to adenomas with dysplasia occurs. Eventually, adenomas that show high-grade dysplasia give rise to invasive colorectal carcinomas.

AmpathChat #52 - Breast Cancer

All individuals with a positive family history of breast or ovarian cancer are not equally at risk. The likelihood that BRCA testing will be informative should be assessed prior to testing.

AmpathChat #51 - Penicillin Allergy

Penicillin allergy is the most commonly reported antibiotic allergy. However, very few patients ever have their penicillin allergy confirmed. Furthermore, less than 20% of patients who report a positive history of a prior reaction to penicillin are found to be allergic to penicillin upon skin prick testing. Avoidance of penicillin based on self-reported allergic history alone often leads to the use of an alternate antibiotic with greater cost or side effect profile.

AmpathChat #50 - Bordetella pertussis

Pertussis, also known as whooping cough, is a highly infectious disease of the respiratory tract. Bordetella pertussis is classically regarded as the sole agent of pertussis. However, infection with other Bordetella species, such as B. parapertussis and B. holmesii, can cause a similar, though typically milder, clinical picture.

AmpathChat #49 - Cystatin C

The prevalence of chronic kidney disease (CKD) and end- stage renal disease is increasing worldwide. Initial diagnosis relies on estimation of the glomerular filtration rate (GFR), and examination of urinary sediment and protein-excretion to establish the presence of kidney damage.

AmpathChat #48 - Expanded chromosome screening of products of conception (POCs)

Ampath Genetics is excited to announce the introduction of products of conception (POCs) testing using next generation sequencing (NGS) technology. NGS allows analysis of all chromosomes (1-22, X and Y), resulting in significantly increased pick-up rates of chromosomal abnormalities when compared to conventional testing approaches.